Malaria caused by Plasmodium spp parasites has an enormous disease burden that disproportionately affects the world’s poorest and youngest.  Our research focuses on elucidating the biology and function of the parasite’s unique plastid organelle, the apicoplast, which is a key anti-malarial drug target.  We take innovative approaches to meet the challenges of studying this complex organism, including a chemical rescue that generates “mutant” parasites lacking their apicoplasts! Investigation of Plasmodium biology offers both the potential for important global health impact and an opportunity to explore fascinating eukaryotic biology.